Millions of Americans can and do safely rely on painkillers with acetaminophen on a regular basis. They also take acetaminophen to lower fever. According to the NIH, they generally have nothing to worry about so long as they do not exceed the maximum dosage for the drug, 4000 mg a day.
If you are taking multiple medications, however, make sure that those drugs do not contain acetaminophen. You could be exceeding the maximum daily dosage and doing harm to your liver.
It’s also unsafe to take acetaminophen if you’re on warfarin, a blood-thinning drug, sometimes known as Coumadin.
And the NIH warns that you should not have more than two alcoholic drinks a day when you are taking acetaminophen.